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MEDICAL BREAKTHOUGH – CNRS Team at the Architecture et Réactivité Uses AIDS Virus To Fight Cancer

According to a CNRS team at the Architecture et Réactivité de l’ARN (RNA Architecture and Reactivity) they have used a specific mutant protein of  the human immunodeficiency virus (HIV), which causes AIDS in addition to a combination with an anticancer drugs to  improve their effectiveness.

Published in PLoS Genetics on August 23rd the CNRS team has selected a “library” of nearly 80 mutant HIV proteins and tested them on tumor cells in the presence of an anticancer drug. The results have enabled them to identify a dCK variant that is more effective than the wild-type (non-mutated) protein, inducing the death of tumor cells in culture which leads to possibility of reducing the doses of anticancer drugs and would palliate the problems posed by their components’ toxicity, reduce their side effects and, most importantly, improve their effectiveness.

The next step in the years to come will be preclinical (animal) studies on the isolated mutant protein. In addition, this experimental system using a normally life-threatening virus is likely to lead to a great many other therapeutic applications.

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Will Kohler

Will Kohler is one of America's best known LGBT historians, He is also a a accredited journalist and the owner of Back2Stonewall.com. A longtime gay activist Will fought on the front lines of the AIDS epidemic with ACT-UP and continues fighting today for LGBT acceptance and full equality. Will’s work has been referenced on such notable media venues as BBC News, CNN, MSNBC, The Washington Post, The Daily Wall Street Journal, Hollywood Reporter, and Raw Story. Back2Stonewall has been recently added to the Library of Congress' LGBTQ+ Studies Web Archive. Mr. Kohler is available for comment, interviews and lectures on LGBT History. Contact: Will@Back2Stonewall.com

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